Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor

The Hippo pathway, which plays a critical role in organ size control and cancer, features numerous WW domain‐based protein–protein interactions. However, ~100 WW domains and 2,000 PY motif‐containing peptide ligands are found in the human proteome, raising a “WW‐PY” binding specificity issue in the...

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Dades bibliogràfiques
Publicat a:EMBO J
Autors principals: Vargas, Rebecca E, Duong, Vy Thuy, Han, Han, Ta, Albert Paul, Chen, Yuxuan, Zhao, Shiji, Yang, Bing, Seo, Gayoung, Chuc, Kimberly, Oh, Sunwoo, El Ali, Amal, Razorenova, Olga V, Chen, Junjie, Luo, Ray, Li, Xu, Wang, Wenqi
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939200/
https://ncbi.nlm.nih.gov/pubmed/31782549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102406
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