Permanent Inactivation of HBV Genomes by CRISPR/Cas9-Mediated Non-cleavage Base Editing

Current antiviral therapy fails to cure chronic hepatitis B virus (HBV) infection because of persistent covalently closed circular DNA (cccDNA). CRISPR/Cas9-mediated specific cleavage of cccDNA is a potentially curative strategy for chronic hepatitis B (CHB). However, the CRISPR/Cas system inevitabl...

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Bibliografski detalji
Izdano u:Mol Ther Nucleic Acids
Glavni autori: Yang, Yu-Chan, Chen, Yu-Hsiang, Kao, Jia-Horng, Ching, Chi, Liu, I-Jung, Wang, Chih-Chiang, Tsai, Cheng-Hsueh, Wu, Fang-Yi, Liu, Chun-Jen, Chen, Pei-Jer, Chen, Ding-Shinn, Yang, Hung-Chih
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7150432/
https://ncbi.nlm.nih.gov/pubmed/32278307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.03.005
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