The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo

Persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) under current antiviral therapy is a major barrier to eradication of chronic hepatitis B (CHB). Curing CHB will require novel strategies for specific disruption of cccDNA. The clustered regularly interspaced short palindr...

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Publicado no:Mol Ther Nucleic Acids
Main Authors: Lin, Su-Ru, Yang, Hung-Chih, Kuo, Yi-Ting, Liu, Chun-Jen, Yang, Ta-Yu, Sung, Ku-Chun, Lin, You-Yu, Wang, Hurng-Yi, Wang, Chih-Chiang, Shen, Yueh-Chi, Wu, Fang-Yi, Kao, Jia-Horng, Chen, Ding-Shinn, Chen, Pei-Jer
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221598/
https://ncbi.nlm.nih.gov/pubmed/25137139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.38
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