Metabolic control analysis of hepatic glycogen synthesis in vivo

Multiple insulin-regulated enzymes participate in hepatic glycogen synthesis, and the rate-controlling step responsible for insulin stimulation of glycogen synthesis is unknown. We demonstrate that glucokinase (GCK)-mediated glucose phosphorylation is the rate-controlling step in insulin-stimulated...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Nozaki, Yuichi, Petersen, Max C., Zhang, Dongyan, Vatner, Daniel F., Perry, Rachel J., Abulizi, Abudukadier, Haedersdal, Sofie, Zhang, Xian-Man, Butrico, Gina M., Samuel, Varman T., Mason, Graeme F., Cline, Gary W., Petersen, Kitt F., Rothman, Douglas L., Shulman, Gerald I.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2020
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7149488/
https://ncbi.nlm.nih.gov/pubmed/32188779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921694117
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