Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease

Gastrointestinal infections often induce epithelial damage that must be repaired for optimal gut function. While intestinal stem cells are critical for this regeneration process [R. C. van der Wath, B. S. Gardiner, A. W. Burgess, D. W. Smith, PLoS One 8, e73204 (2013); S. Kozar et al., Cell Stem Cel...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mileto, Steven J., Jardé, Thierry, Childress, Kevin O., Jensen, Jaime L., Rogers, Ashleigh P., Kerr, Genevieve, Hutton, Melanie L., Sheedlo, Michael J., Bloch, Sarah C., Shupe, John A., Horvay, Katja, Flores, Tracey, Engel, Rebekah, Wilkins, Simon, McMurrick, Paul J., Lacy, D. Borden, Abud, Helen E., Lyras, Dena
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7149309/
https://ncbi.nlm.nih.gov/pubmed/32198200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915255117
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