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A Two-Component regulatory system with opposite effects on glycopeptide antibiotic biosynthesis and resistance
The glycopeptide A40926, produced by the actinomycete Nonomuraea gerenzanensis, is the precursor of dalbavancin, a second-generation glycopeptide antibiotic approved for clinical use in the USA and Europe in 2014 and 2015, respectively. The final product of the biosynthetic pathway is an O-acetylate...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7148328/ https://ncbi.nlm.nih.gov/pubmed/32277112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63257-4 |
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