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Heterologous Expression of the Thiopeptide Antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor Requires Deletion of Ribosomal Genes from the Expression Construct

GE2270 is a thiopeptide antibiotic generated by extensive posttranslational modifications of a ribosomally generated precursor peptide. Thiopeptides are especially active against Gram-positive bacteria, including methicillin resistant Staphylococcus aureus (MRSA). In this study the GE2270 biosynthet...

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Bibliografiske detaljer
Main Authors: Flinspach, Katrin, Kapitzke, Claudia, Tocchetti, Arianna, Sosio, Margherita, Apel, Alexander K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943966/
https://ncbi.nlm.nih.gov/pubmed/24598591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090499
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