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Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway
In mammalian cells, mitochondrial dysfunction triggers the integrated stress response (ISR), in which eIF2α phosphorylation induces the transcription factor ATF4(1-3). However, how mitochondrial stress is relayed to ATF4 is unknown. We found that HRI is the eIF2α kinase necessary and sufficient for...
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| Pubblicato in: | Nature |
|---|---|
| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7147832/ https://ncbi.nlm.nih.gov/pubmed/32132707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2078-2 |
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