Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: a single oral dose study before and after surgery

OBJECTIVE: Roux-en-Y gastric bypass (RYGB) surgery induces major changes in the gastrointestinal tract that may alter the pharmacokinetics of orally administered drugs. Results from pharmacokinetic studies are sparse. This study aimed to investigate the effect of RYGB on the bioavailability of metop...

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Publicado en:Eur J Hosp Pharm
Autores principales: Yska, Jan Peter, Wanders, Jacquelien T M, Odigie, Blessing, Apers, Jan A, Emous, Marloes, Totté, Erik R E, Boerma, E Christiaan, Ubels, Froukje L, Woerdenbag, Herman J, Frijlink, Henderik W, Wilffert, Bob, van Roon, Eric N
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2020
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147559/
https://ncbi.nlm.nih.gov/pubmed/32296500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ejhpharm-2018-001804
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