Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: a single oral dose study before and after surgery

OBJECTIVE: Roux-en-Y gastric bypass (RYGB) surgery induces major changes in the gastrointestinal tract that may alter the pharmacokinetics of orally administered drugs. Results from pharmacokinetic studies are sparse. This study aimed to investigate the effect of RYGB on the bioavailability of metop...

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Detalhes bibliográficos
Publicado no:Eur J Hosp Pharm
Main Authors: Yska, Jan Peter, Wanders, Jacquelien T M, Odigie, Blessing, Apers, Jan A, Emous, Marloes, Totté, Erik R E, Boerma, E Christiaan, Ubels, Froukje L, Woerdenbag, Herman J, Frijlink, Henderik W, Wilffert, Bob, van Roon, Eric N
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147559/
https://ncbi.nlm.nih.gov/pubmed/32296500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ejhpharm-2018-001804
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