Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment

BACKGROUND: Osteoclast activation is a hallmark of breast cancer-induced bone disease while little is known about the role of osteoblasts in this process. Recently, we identified the homeodomain protein TG-interacting factor-1 (Tgif1) as a crucial regulator of osteoblast function. In this study, we...

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Pubblicato in:Breast Cancer Res
Autori principali: Haider, Marie-Therese, Saito, Hiroaki, Zarrer, Jennifer, Uzhunnumpuram, Kevin, Nagarajan, Sankari, Kari, Vijayalakshmi, Horn-Glander, Michael, Werner, Stefan, Hesse, Eric, Taipaleenmäki, Hanna
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7146874/
https://ncbi.nlm.nih.gov/pubmed/32272947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-020-01269-8
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