TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone

Osteoporosis is caused by increased bone resorption and decreased bone formation. Intermittent administration of a fragment of Parathyroid hormone (PTH) activates osteoblast-mediated bone formation and is used in patients with severe osteoporosis. However, the mechanisms by which PTH elicits its ana...

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Опубликовано в: :Nat Commun
Главные авторы: Saito, Hiroaki, Gasser, Andreas, Bolamperti, Simona, Maeda, Miki, Matthies, Levi, Jähn, Katharina, Long, Courtney L., Schlüter, Hartmut, Kwiatkowski, Marcel, Saini, Vaibhav, Pajevic, Paola Divieti, Bellido, Teresita, van Wijnen, Andre J., Mohammad, Khalid S., Guise, Theresa A., Taipaleenmäki, Hanna, Hesse, Eric
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430773/
https://ncbi.nlm.nih.gov/pubmed/30902975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08778-x
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