A nucleotide-dependent oligomerization of the Escherichia coli replication initiator DnaA requires residue His136 for remodeling of the chromosomal origin

Escherichia coli replication initiator protein DnaA binds ATP with high affinity but the amount of ATP required to initiate replication greatly exceeds the amount required for binding. Previously, we showed that ATP-DnaA, not ADP-DnaA, undergoes a conformational change at the higher nucleotide conce...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Saxena, Rahul, Stanley, Christopher B, Kumar, Pankaj, Cuneo, Matthew J, Patil, Digvijay, Jha, Jyoti, Weiss, Kevin L, Chattoraj, Dhruba K, Crooke, Elliott
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145717/
https://ncbi.nlm.nih.gov/pubmed/31665475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz939
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