A nucleotide-dependent oligomerization of the Escherichia coli replication initiator DnaA requires residue His136 for remodeling of the chromosomal origin

Escherichia coli replication initiator protein DnaA binds ATP with high affinity but the amount of ATP required to initiate replication greatly exceeds the amount required for binding. Previously, we showed that ATP-DnaA, not ADP-DnaA, undergoes a conformational change at the higher nucleotide conce...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Saxena, Rahul, Stanley, Christopher B, Kumar, Pankaj, Cuneo, Matthew J, Patil, Digvijay, Jha, Jyoti, Weiss, Kevin L, Chattoraj, Dhruba K, Crooke, Elliott
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145717/
https://ncbi.nlm.nih.gov/pubmed/31665475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz939
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