Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation

Alternative splicing is emerging as an oncogenic mechanism. In prostate cancer, generation of constitutively active forms of androgen receptor (AR) variants including AR-V7 plays an important role in progression of castration-resistant prostate cancer (CRPC). AR-V7 is generated by alternative splici...

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Опубликовано в: :Nucleic Acids Res
Главные авторы: Duan, Lingling, Chen, Zhenhua, Lu, Jun, Liang, Yanping, Wang, Ming, Roggero, Carlos M, Zhang, Qing-Jun, Gao, Jason, Fang, Yong, Cao, Jiazheng, Lu, Jian, Zhao, Hongwei, Dang, Andrew, Pong, Rey-Chen, Hernandez, Elizabeth, Chang, Chun-Mien, Hoang, David T, Ahn, Jung-Mo, Xiao, Guanghua, Wang, Rui-tao, Yu, Kai-jiang, Kapur, Payal, Rizo, Josep, Hsieh, Jer-Tsong, Luo, Junhang, Liu, Zhi-Ping
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Gene regulation, Chromatin and Epigenetics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145715/
https://ncbi.nlm.nih.gov/pubmed/31647098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1004
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