Targeted DNA methylation of neurodegenerative disease genes via homology directed repair

DNA methyltransferases (DNMTs) are thought to be involved in the cellular response to DNA damage, thus linking DNA repair mechanisms with DNA methylation. In this study we present Homology Assisted Repair Dependent Epigenetic eNgineering (HARDEN), a novel method of targeted DNA methylation that util...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Cali, Christopher P, Park, Daniel S, Lee, Edward B
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Gene regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145628/
https://ncbi.nlm.nih.gov/pubmed/31680172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz979
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