A novel EZH2 inhibitor induces synthetic lethality and apoptosis in PBRM1-deficient cancer cells

The inhibition of enhancer of zeste homolog 2 (EZH2) has been suggested to be synthetic lethal with polybromo-1 (PBRM1) deficiency, rendering EZH2 to be an attractive target for the treatment of PBRM1 frequently mutated cancers. In the current study, we combined computational and biochemical approac...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Huang, Kejia, Sun, Rong, Chen, Jiarong, Yang, Qianye, Wang, Yucheng, Zhang, Yang, Xie, Kun, Zhang, Tiantian, Li, Rui, Zhao, Qi, Zou, Liang, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145336/
https://ncbi.nlm.nih.gov/pubmed/32093567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2020.1729450
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