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Inhibition of cytoplasmic cap methylation identifies 5′ TOP mRNAs as recapping targets and reveals recapping sites downstream of native 5′ ends

Cap homeostasis is the cyclical process of decapping and recapping that maintains the translation and stability of a subset of the transcriptome. Previous work showed levels of some recapping targets decline following transient expression of an inactive form of RNMT (ΔN-RNMT), likely due to degradat...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: del Valle Morales, Daniel, Trotman, Jackson B, Bundschuh, Ralf, Schoenberg, Daniel R
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144985/
https://ncbi.nlm.nih.gov/pubmed/31996904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa046
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