Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer

MORC family CW-type zinc finger 2 (MORC2) is an oncogenic chromatin-remodeling enzyme with an emerging role in DNA repair. Here, we report a novel function for MORC2 in cell-cycle checkpoint control through an acetylation-dependent mechanism. MORC2 is acetylated by the acetyltransferase NAT10 at lys...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Liu, Hong-Yi, Liu, Ying-Ying, Yang, Fan, Zhang, Lin, Zhang, Fang-Lin, Hu, Xin, Shao, Zhi-Min, Li, Da-Qiang
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144926/
https://ncbi.nlm.nih.gov/pubmed/32112098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa130
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker