HDAC3 functions as a positive regulator in Notch signal transduction

Aberrant Notch signaling plays a pivotal role in T-cell acute lymphoblastic leukemia (T-ALL) and chronic lymphocytic leukemia (CLL). Amplitude and duration of the Notch response is controlled by ubiquitin-dependent proteasomal degradation of the Notch1 intracellular domain (NICD1), a hallmark of the...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Ferrante, Francesca, Giaimo, Benedetto Daniele, Bartkuhn, Marek, Zimmermann, Tobias, Close, Viola, Mertens, Daniel, Nist, Andrea, Stiewe, Thorsten, Meier-Soelch, Johanna, Kracht, Michael, Just, Steffen, Klöble, Patricia, Oswald, Franz, Borggrefe, Tilman
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144913/
https://ncbi.nlm.nih.gov/pubmed/32107550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa088
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