HDAC3 functions as a positive regulator in Notch signal transduction

Aberrant Notch signaling plays a pivotal role in T-cell acute lymphoblastic leukemia (T-ALL) and chronic lymphocytic leukemia (CLL). Amplitude and duration of the Notch response is controlled by ubiquitin-dependent proteasomal degradation of the Notch1 intracellular domain (NICD1), a hallmark of the...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Principais autores: Ferrante, Francesca, Giaimo, Benedetto Daniele, Bartkuhn, Marek, Zimmermann, Tobias, Close, Viola, Mertens, Daniel, Nist, Andrea, Stiewe, Thorsten, Meier-Soelch, Johanna, Kracht, Michael, Just, Steffen, Klöble, Patricia, Oswald, Franz, Borggrefe, Tilman
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144913/
https://ncbi.nlm.nih.gov/pubmed/32107550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa088
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