Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading

Aging is associated with a gradual decline of cellular proteostasis, giving rise to devastating protein misfolding diseases, such as Alzheimer disease (AD) or Parkinson disease (PD). These diseases often exhibit a complex pathology involving non-cell autonomous proteotoxic effects, which are still p...

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Bibliographic Details
Published in:Autophagy
Main Authors: Sandhof, Carl Alexander, Hoppe, Simon Oliver, Druffel-Augustin, Silke, Gallrein, Christian, Kirstein, Janine, Voisine, Cindy, Nussbaum-Krammer, Carmen
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2019
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144869/
https://ncbi.nlm.nih.gov/pubmed/31354022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1643657
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