Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

The use of hiPSC-derived cells represents a valuable approach to study human neurodegenerative diseases. Here, we describe an optimized protocol for the differentiation of hiPSCs derived from a patient with the triplication of the alpha-synuclein gene (SNCA) locus into Parkinson’s disease (PD)-relev...

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Bibliografiske detaljer
Udgivet i:J Vis Exp
Main Authors: Tagliafierro, Lidia, Ilich, Ekatarina, Moncalvo, Malik, Gu, Jeffrey, Sriskanda, Ahila, Grenier, Carole, Murphy, Susan K., Chiba-Falek, Ornit, Kantor, Boris
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144461/
https://ncbi.nlm.nih.gov/pubmed/30985756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/59241
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