PTGES/PGE(2) signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model

Chronic inflammation has been linked to promotion of tumorigenesis and metastasis in lung. However, due to lack of a relevant animal model for characterization, the underlying mechanism remains elusive. Lung tumor suppressor gene Gprc5a-knockout (ko) mice are susceptible to lung inflammation, tumori...

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Udgivet i:Oncogene
Main Authors: Wang, Tong, Jing, Bo, Xu, Dongliang, Liao, Yueling, Song, Hongyong, Sun, Beibei, Guo, Wenzheng, Xu, Jianhua, Li, Kaimi, Hu, Min, Liu, Shuli, Ling, Jing, Kuang, Yanbin, Zhang, Tuo, Zhang, Siwei, Yao, Feng, Zhou, Binhua P., Deng, Jiong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142021/
https://ncbi.nlm.nih.gov/pubmed/32060421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1207-6
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