EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma

The oncogene epidermal growth factor receptor variant III (EGFRvIII) is frequently expressed in glioblastomas (GBM) but its impact on therapy response is still under controversial debate. Here we wanted to test if EGFRvIII influences the sensitivity towards the alkylating agent temozolomide (TMZ). T...

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Publicado en:Oncogene
Main Authors: Struve, Nina, Binder, Zev A., Stead, Lucy F., Brend, Tim, Bagley, Stephen J., Faulkner, Claire, Ott, Leonie, Müller-Goebel, Justus, Weik, Anna-Sophie, Hoffer, Konstantin, Krug, Leonie, Rieckmann, Thorsten, Bußmann, Lara, Henze, Marvin, Morrissette, Jennifer J. D., Kurian, Kathreena M., Schüller, Ulrich, Petersen, Cordula, Rothkamm, Kai, O´ Rourke, Donald M., Short, Susan C., Kriegs, Malte
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142016/
https://ncbi.nlm.nih.gov/pubmed/32066879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1208-5
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