The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically

The homeotic protein SIX3 is a transcription factor vital for neurogenesis and has a bivalent promoter. We previously showed that SIX3 can be transcriptionally silenced by DNA hypermethylation, functions as a tumor suppressor gene, and inhibits human glioblastoma transcriptionally. Here, we show tha...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Yu, Zhibin, Feng, Jianbo, Wang, Wei, Deng, Zhiyong, Zhang, Yan, Xiao, Lan, Wang, Zeyou, Liu, Changhong, Liu, Qing, Chen, Shuai, Wu, Minghua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7142014/
https://ncbi.nlm.nih.gov/pubmed/32051553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1206-7
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