Epigenetic silencing of miR-338 facilitates glioblastoma progression by de-repressing the pyruvate kinase M2-β-catenin axis

Glioblastoma is the most malignant type of brain tumor, and its high invasiveness and multiplication severely shortens patients’ overall survival. The embryonic pyruvate kinase M2 (PKM2) isoform is highly expressed in human cancer. We used computational target gene prediction, in vitro cell culture,...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Han, Bo, Meng, Xiangqi, Chen, Hui, Chen, Lingchao, Liu, Xing, Wang, Hongjun, Liu, Daming, Gao, Fei, Lin, Lin, Ming, Jianguang, Sun, Bo, Yin, Shi, Wang, Ruijia, Wu, Pengfei, Cai, Jinquan, Jiang, Chuanlu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5611983/
https://ncbi.nlm.nih.gov/pubmed/28858851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101271
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