Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease

Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist fingolimod (FTY720) attenuates psychosine-ind...

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Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Béchet, Sibylle, O'Sullivan, Sinead A., Yssel, Justin, Fagan, Steven G., Dev, Kumlesh K.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2020
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141882/
https://ncbi.nlm.nih.gov/pubmed/32127495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2346-19.2020
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