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Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease
Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist fingolimod (FTY720) attenuates psychosine-ind...
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| Veröffentlicht in: | J Neurosci |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Society for Neuroscience
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7141882/ https://ncbi.nlm.nih.gov/pubmed/32127495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2346-19.2020 |
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