Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease

Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist fingolimod (FTY720) attenuates psychosine-ind...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Béchet, Sibylle, O'Sullivan, Sinead A., Yssel, Justin, Fagan, Steven G., Dev, Kumlesh K.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141882/
https://ncbi.nlm.nih.gov/pubmed/32127495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2346-19.2020
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