CRISPRitz: rapid, high-throughput and variant-aware in silico off-target site identification for CRISPR genome editing

MOTIVATION: Clustered regularly interspaced short palindromic repeats (CRISPR) technologies allow for facile genomic modification in a site-specific manner. A key step in this process is the in silico design of single guide RNAs to efficiently and specifically target a site of interest. To this end,...

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Bibliografiske detaljer
Udgivet i:Bioinformatics
Main Authors: Cancellieri, Samuele, Canver, Matthew C, Bombieri, Nicola, Giugno, Rosalba, Pinello, Luca
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
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Original Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141852/
https://ncbi.nlm.nih.gov/pubmed/31764961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btz867
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