Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation

The many variants of human Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) differ in the lengths and sequences of disordered linkers connecting the kinase domains to the oligomeric hubs of the holoenzyme. CaMKII activity depends on the balance between activating and inhibitory autophosphoryla...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:eLife
Päätekijät: Bhattacharyya, Moitrayee, Lee, Young Kwang, Muratcioglu, Serena, Qiu, Baiyu, Nyayapati, Priya, Schulman, Howard, Groves, Jay T, Kuriyan, John
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: eLife Sciences Publications, Ltd 2020
Aiheet:
Biochemistry and Chemical Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141811/
https://ncbi.nlm.nih.gov/pubmed/32149607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53670
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