Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is an oligomeric enzyme with crucial roles in neuronal signaling and cardiac function. Previously, we showed that activation of CaMKII triggers the exchange of subunits between holoenzymes, potentially increasing the spread of the active state (...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Karandur, Deepti, Bhattacharyya, Moitrayee, Xia, Zijie, Lee, Young Kwang, Muratcioglu, Serena, McAffee, Darren, McSpadden, Ethan D, Qiu, Baiyu, Groves, Jay T, Williams, Evan R, Kuriyan, John
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Biochemistry and Chemical Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7538161/
https://ncbi.nlm.nih.gov/pubmed/32902386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57784
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