Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

The activation of the dodecameric Ca(2+)/calmodulin dependent kinase II (CaMKII) holoenzyme is critical for memory formation. We now report that CaMKII has a remarkable property, which is that activation of the holoenzyme triggers the exchange of subunits between holoenzymes, including unactivated o...

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Detalhes bibliográficos
Main Authors: Stratton, Margaret, Lee, Il-Hyung, Bhattacharyya, Moitrayee, Christensen, Sune M, Chao, Luke H, Schulman, Howard, Groves, Jay T, Kuriyan, John
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901001/
https://ncbi.nlm.nih.gov/pubmed/24473075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01610
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