Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques

Dengue virus (DENV) is transmitted by infectious mosquitoes during blood-feeding via saliva containing biologically-active proteins. Here, we examined the effect of varying DENV infection modality in rhesus macaques in order to improve the DENV nonhuman primate (NHP) challenge model. NHPs were expos...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: McCracken, Michael K., Gromowski, Gregory D., Garver, Lindsey S., Goupil, Brad A., Walker, Kathryne D., Friberg, Heather, Currier, Jeffrey R., Rutvisuttinunt, Wiriya, Hinton, Kevin L., Christofferson, Rebecca C., Mores, Christopher N., Vanloubbeeck, Yannick, Lorin, Clarisse, Malice, Marie-Pierre, Thomas, Stephen J., Jarman, Richard G., Vaughn, David W., Putnak, J. Robert, Warter, Lucile
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141610/
https://ncbi.nlm.nih.gov/pubmed/32267846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008191
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