Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques

Dengue virus (DENV) is transmitted by infectious mosquitoes during blood-feeding via saliva containing biologically-active proteins. Here, we examined the effect of varying DENV infection modality in rhesus macaques in order to improve the DENV nonhuman primate (NHP) challenge model. NHPs were expos...

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Vydáno v:PLoS Negl Trop Dis
Hlavní autoři: McCracken, Michael K., Gromowski, Gregory D., Garver, Lindsey S., Goupil, Brad A., Walker, Kathryne D., Friberg, Heather, Currier, Jeffrey R., Rutvisuttinunt, Wiriya, Hinton, Kevin L., Christofferson, Rebecca C., Mores, Christopher N., Vanloubbeeck, Yannick, Lorin, Clarisse, Malice, Marie-Pierre, Thomas, Stephen J., Jarman, Richard G., Vaughn, David W., Putnak, J. Robert, Warter, Lucile
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141610/
https://ncbi.nlm.nih.gov/pubmed/32267846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008191
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