Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis

Extracellular cold-inducible RNA-binding protein (eCIRP) is a recently discovered damage-associated molecular pattern. Understanding the precise mechanism by which it exacerbates inflammation is essential. Here we identified that eCIRP is a new biologically active endogenous ligand of triggering rec...

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Udgivet i:JCI Insight
Main Authors: Denning, Naomi-Liza, Aziz, Monowar, Murao, Atsushi, Gurien, Steven D., Ochani, Mahendar, Prince, Jose M., Wang, Ping
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141396/
https://ncbi.nlm.nih.gov/pubmed/32027618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134172
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