The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP

Maintaining cellular proteostasis is essential for oligodendrocyte viability and function; however, its underlying mechanisms remain unexplored. Unfolded protein response (UPR), which comprises 3 parallel branches, inositol requiring enzyme 1 (IRE1), pancreatic ER kinase (PERK), and activating trans...

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Detalles Bibliográficos
Publicado en:JCI Insight
Main Authors: Stone, Sarrabeth, Wu, Shuangchan, Nave, Klaus-Armin, Lin, Wensheng
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141389/
https://ncbi.nlm.nih.gov/pubmed/32053121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132364
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