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The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP
Maintaining cellular proteostasis is essential for oligodendrocyte viability and function; however, its underlying mechanisms remain unexplored. Unfolded protein response (UPR), which comprises 3 parallel branches, inositol requiring enzyme 1 (IRE1), pancreatic ER kinase (PERK), and activating trans...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7141389/ https://ncbi.nlm.nih.gov/pubmed/32053121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132364 |
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