The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia

Acute myeloid leukemia is a heterogeneous disease with a 5-year survival rate of 28.3%, and current treatment options constrained by dose-limiting toxicities. One of the key signaling pathways known to be frequently activated and dysregulated in AML is PI3K/AKT. Its dysregulation is associated with...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Annageldiyev, Charyguly, Tan, Su-Fern, Thakur, Shreya, Dhanyamraju, Pavan Kumar, Ramisetti, Srinivasa R., Bhadauria, Preeti, Schick, Jacob, Zeng, Zheng, Sharma, Varun, Dunton, Wendy, Dovat, Sinisa, Desai, Dhimant, Zheng, Hong, Feith, David J., Loughran, Thomas P., Amin, Shantu, Sharma, Arun K., Claxton, David, Sharma, Arati
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140985/
https://ncbi.nlm.nih.gov/pubmed/32296637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00393
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