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Impaired Replication Timing Promotes Tissue-Specific Expression of Common Fragile Sites

Common fragile sites (CFSs) are particularly vulnerable regions of the genome that become visible as breaks, gaps, or constrictions on metaphase chromosomes when cells are under replicative stress. Impairment in DNA replication, late replication timing, enrichment of A/T nucleotides that tend to for...

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Detalhes bibliográficos
Publicado no:Genes (Basel)
Main Authors: Maccaroni, Klizia, Balzano, Elisa, Mirimao, Federica, Giunta, Simona, Pelliccia, Franca
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140878/
https://ncbi.nlm.nih.gov/pubmed/32204553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11030326
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