Gene expression responses to anti-tuberculous drugs in a whole blood model

BACKGROUND: There is a need for better tools to evaluate new or repurposed TB drugs. The whole blood bactericidal activity (WBA) assay has been advocated for this purpose. We investigated whether transcriptional responses in the WBA assay resemble TB responses in vivo, and whether the approach might...

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Detalhes bibliográficos
Publicado no:BMC Microbiol
Main Authors: Kwan, Philip Kam Weng, Lin, Wenwei, Naim, Ahmad Nazri Mohamed, Periaswamy, Balamurugan, De Sessions, Paola Florez, Hibberd, Martin L., Paton, Nicholas I.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140558/
https://ncbi.nlm.nih.gov/pubmed/32264819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12866-020-01766-y
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