Adjunctive use of celecoxib with anti-tuberculosis drugs: evaluation in a whole-blood bactericidal activity model

COX-2 inhibition may be of benefit in the treatment of tuberculosis (TB) through a number of pathways including efflux pump inhibition (increasing intracellular TB drug levels) and diverse effects on inflammation and the immune response. We investigated celecoxib (a COX-2 inhibitor) alone and with s...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Naftalin, Claire M., Verma, Rupangi, Gurumurthy, Meera, Hee, Kim Hor, Lu, Qingshu, Yeo, Benjamin Chaik Meng, Tan, Kin Hup, Lin, Wenwei, Yu, Buduo, Seng, Kok Yong, Lee, Lawrence Soon-U, Paton, Nicholas I.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131161/
https://ncbi.nlm.nih.gov/pubmed/30202030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31590-4
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