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Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies

The human 80S ribosome is the cellular nucleoprotein nanomachine in charge of protein synthesis that is profoundly affected during cancer transformation by oncogenic proteins and provides cancerous proliferating cells with proteins and therefore biomass. Indeed, cancer is associated with an increase...

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Détails bibliographiques
Publié dans:Cells
Auteurs principaux: Gilles, Arnaud, Frechin, Léo, Natchiar, Kundhavai, Biondani, Giulia, von Loeffelholz, Ottilie, Holvec, Samuel, Malaval, Julie-Lisa, Winum, Jean-Yves, Klaholz, Bruno P., Peyron, Jean-François
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140421/
https://ncbi.nlm.nih.gov/pubmed/32151059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9030629
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