Vitamin D3 Metabolites Demonstrate Prognostic Value in EGFR-Mutant Lung Adenocarcinoma and Can be Deployed to Oppose Acquired Therapeutic Resistance

EGFR tyrosine kinase inhibitors (EGFR TKIs) are the standard of care treatment for patients with EGFR-mutant lung adenocarcinoma (LUAD). Although initially effective, EGFR TKIs are not curative. Disease inevitably relapses due to acquired drug resistance. We hypothesized that vitamin D metabolites c...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Shaurova, Tatiana, Dy, Grace K, Battaglia, Sebastiano, Hutson, Alan, Zhang, Letian, Zhang, Yunkai, Lovly, Christine M, Seshadri, Mukund, Goodrich, David W, Johnson, Candace S, Hershberger, Pamela A
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140110/
https://ncbi.nlm.nih.gov/pubmed/32183160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12030675
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