Understanding Lineage Plasticity as a Path to Targeted Therapy Failure in EGFR-Mutant Non-small Cell Lung Cancer

Somatic alterations in the epidermal growth factor receptor gene (EGFR) result in aberrant activation of kinase signaling and occur in ∼15% of non-small cell lung cancers (NSCLC). Patients diagnosed with EGFR-mutant NSCLC have good initial clinical response to EGFR tyrosine kinase inhibitors (EGFR T...

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Bibliographic Details
Published in:Front Genet
Main Authors: Shaurova, Tatiana, Zhang, Letian, Goodrich, David W., Hershberger, Pamela A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7121227/
https://ncbi.nlm.nih.gov/pubmed/32292420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00281
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