Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2—A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling

Antisense Oligonucleotides (ASOs) are an emerging drug class in gene modification. In our study we developed a safe, stable, and effective ASO drug candidate in locked nucleic acid (LNA)-gapmer design, targeting TGFβ receptor II (TGFBR2) mRNA. Discovery was performed as a process using state-of-the-...

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Publicat a:Int J Mol Sci
Autors principals: Kuespert, Sabrina, Heydn, Rosmarie, Peters, Sebastian, Wirkert, Eva, Meyer, Anne-Louise, Siebörger, Mareile, Johannesen, Siw, Aigner, Ludwig, Bogdahn, Ulrich, Bruun, Tim-Henrik
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7139664/
https://ncbi.nlm.nih.gov/pubmed/32178467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21061952
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