Towards Zwitterionic Oligonucleotides with Improved Properties: the NAA/LNA‐Gapmer Approach

Oligonucleotides (ON) are promising therapeutic candidates, for instance by blocking endogenous mRNA (antisense mechanism). However, ON usually require structural modifications of the native nucleic acid backbone to ensure satisfying pharmacokinetic properties. One such strategy to design novel anti...

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Bibliographische Detailangaben
Veröffentlicht in:Chembiochem
Hauptverfasser: Wojtyniak, Melissa, Schmidtgall, Boris, Kirsch, Philine, Ducho, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754139/
https://ncbi.nlm.nih.gov/pubmed/32662164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000450
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