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Enhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological Media †

Deficient stability towards nuclease-mediated degradation is one of the most relevant tasks in the development of oligonucleotide-derived biomedical agents. This hurdle can be overcome through modifications to the native oligonucleotide backbone structure, with the goal of simultaneously retaining t...

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Bibliografische gegevens
Gepubliceerd in:Molecules
Hoofdauteurs: Meng, Melissa, Schmidtgall, Boris, Ducho, Christian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6278555/
https://ncbi.nlm.nih.gov/pubmed/30423832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23112941
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