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Enhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological Media †
Deficient stability towards nuclease-mediated degradation is one of the most relevant tasks in the development of oligonucleotide-derived biomedical agents. This hurdle can be overcome through modifications to the native oligonucleotide backbone structure, with the goal of simultaneously retaining t...
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| Publicado no: | Molecules |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6278555/ https://ncbi.nlm.nih.gov/pubmed/30423832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23112941 |
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