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Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion

ISWI chromatin remodeling ATPase SMARCA5 (SNF2H) is a well-known factor for its role in regulation of DNA access via nucleosome sliding and assembly. SMARCA5 transcriptionally inhibits the myeloid master regulator PU.1. Upregulation of SMARCA5 was previously observed in CD34+ hematopoietic progenito...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Zikmund, Tomas, Paszekova, Helena, Kokavec, Juraj, Kerbs, Paul, Thakur, Shefali, Turkova, Tereza, Tauchmanova, Petra, Greif, Philipp A., Stopka, Tomas
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7139293/
https://ncbi.nlm.nih.gov/pubmed/32197313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21062073
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